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KMID : 0616120230540030089
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Korean Journal of Pharmacognosy
2023 Volume.54 No. 3 p.89 ~ p.95
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Antioxidant Response Element Induction and Anti-skeletal Muscle Atrophic Activity of Isocoumarins from Eupolyphaga sinensis
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Kaixuan Zhang
Kim Jae-Yong
Kim Ji-Hoon
Jeon Je-Seung
Kim Chul-Young
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Abstract
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Eupolyphaga sinensis Walker, belonging to the family Corydiidae (Blattodea), is common in Southeast Asia. Due to its richness in nutrients, E. sinensis is usually used in traditional Oriental medicine as a basic component of anticoagulant and immune-enhancing remedies. Isolation from ethanol extract of E. sinensis yielded seven compounds, two isocoumarins (1 and 2) and four phenolic compounds 3-6. Their chemical structures were elucidated as (R)-6,8-dihydroxy-3,7-dimethyl-3,4-dihydroisochromen-1-one (monaschromone) (1), (R)-3-ethyl-6,8-dihydroxy-7-methyl-3,4-dihydroisochromen-1-one (2), 3-methoxytyramine (3), hydroxyphenyl acetic acid (4), dihydroferulic acid (5), and protocatechuic acid (6), by spectroscopic analysis. Among them, compounds 3-6 were first found in E. sinensis. Additionally, the two isocoumarins, 1 and 2, exhibited biological activity such as enhancing antioxidant response element and preventing dexamethasone-induced skeletal muscle atrophy in C2C12 myotubes.
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KEYWORD
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Eupolyphaga sinensis Walker, Isocoumarins, Phenolic compounds, Antioxidant response element, Skeletal
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